Acetone → 2-(6-Bromopyridin-2-yl)propan-2-ol

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2,6-dibromopyridine (1.0 eq.) in Et2O (0.2M) at −78° C. was added dropwise n-BuLi (1.05 eq.). The mixture was stirred at −78° C. for 45 min then acetone (1.5 eq.) was added. The final mixture was stirred for an extra 15 min at −78° C. and quenched with saturated aqueous NaHCO3. The mixture was extracted with EtOAc (2×). The combined organic extracts were washed with, brine, dried over MgSO4, filtered and concentrated to afford the title compound as a white solid which was used as such.

Provenance & Evidence