Sodium Bicarbonate → HCID 69373967, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-{3′-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-biphenyl-3-yl}-acrylic acid methyl ester (1.0 eq.) from EXAMPLE 11, Step 2, in Tol (0.1M) at was added benzenesulfonyl hydrazide (3.8 eq.). The mixture was stirred at 100° C. for 12 h, cooled to rt, poured in saturated aqueous NaHCO3 and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. Flash chromatography (CH2Cl2:EtOAc; 8.5:1.5) afforded the title compound as a white solid.

Provenance & Evidence