Acetic Acid → HCID 10367597, compound

Participants

Reaction Steps

To a solution of 3-{3′-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-biphenyl-3-yl}-propionic acid methyl ester (1.0 eq.) from step 1, in TBF:MeOH (2:1; 0.2M) was added aqueous LiOH (2M; 4.0 eq.). The mixture was stirred for 12 h at rt, quenched with AcOH (20 eq.), poured in saturated aqueous NH4OAc and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. Crystallization in Hex:CH2Cl2 afforded the title compound as a white solid.

Provenance & Evidence