Trifluoroacetic acid → HCID 10047632, compound

Participants

Reaction Steps

To a solution of 8-[3-(6-Benzyloxy-pyridin-3-yl)-phenyl]-6-(1-methanesulfonyl-1-methyl-ethyl)-quinoline from Step 2 (1.0 eq.) in CH2Cl2 (0.2M) was added an equi volume of TFA. The mixture was stirred for 72 h, concentrated, poured in saturated aqueous NaHCO3 and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. Flash chromatography (CH2Cl2:MeOH; 95:5) afforded the title compound as a light yellow solid. 1H NMR (500 MHz, DMSO-d6): δ 8.95 (dd, 1H), 8.53 (d, 1H), 8.28 (d, 1H), 8.04 (d, 1H), 7.89 (dd, 1H), 7.79 (s, 1H), 7.75 (s, NH), 7.63–7.53 (m, 4H), 6.46 (d, 1H), 2.82 (s, 3H), 1.94 (s, 6H).

Provenance & Evidence