HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl isocyanate → HCID 901017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 901017 | HCID 901017 | — |
Reaction Steps
To a solution of 2-amino-5-bromo-pyridine (1.05 eq.) in TBF (0.2M) was added DBU (1.0 eq.) followed by iso-propyl-isocyanate (1.0 eq.). The mixture was stirred for 12 h, diluted with CH2Cl2, washed with brine, dried over MgSO4, filtered and concentrated. Crystallization from acetone afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153968B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-3f06e1b7e3ca49f1a12089c09a323654 |
| Source note | uspto-grants-2006_12 |