HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861011Generated: October 26, 2026
Hydrochloric Acid → 3-{6-[1-Methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoic acid
https://huagongshe.com/reaction/861011
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoate | HCID 68887704 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-{6-[1-Methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoic acid | HCID 21865566 | — |
Reaction Steps
To a solution of 3-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-benzoic acid methyl ester from Step 1 (1.0 eq.) in THF (0.2M) was added aqueous LiOH (1.0M; 3.0 eq.). The mixture was stirred for 5 h at 60° C., neutralized to pH=5 using aqueous HCl (1M) and extracted with CH2Cl2 (4×). The combined organic extracts were dried over MgSO4, filtered and concentrated. Stirring in Hex:Et2O (1:1) afforded the title compound after filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07153968B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-5bf5b0d2373e4b8690489512cf904019 |
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| Source note | uspto-grants-2006_12 |
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