HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl trans-4-Bromocinnamate | HCID 688115 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
Reaction Steps
To a solution of E-3-(4-bromo-phenyl)-acrylic acid ethyl ester and Pd(OAc)2 (0.05 eq.) in THF (0.2M) was added portionwise CH2N2 until the reaction was completed. NMR of aliquots monitored the reaction. The resulting mixture was concentrated and filtered on celite to afford the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153968B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-0a126e1545b940fdb057550d8c3a0fa8 |
| Source note | uspto-grants-2006_12 |