Lithium Hydroxide → HCID 10345293, compound

Participants

Reaction Steps

To a solution of 2-{3′[6-(1-methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-biphenyl 4-yl}-cyclopropanecarboxylic acid ethyl ester (1.0 eq.) from Step 1, in THF:MEOH (2:1; 0.2M) was added aqueous LiOH (2M; 0.2.0 eq.). The mixture was stirred for 12 h at rt, quenched with HCl 10% and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. Crystallization in Hex:EtOAc afforded the title compound as a white solid. 1H NMR (400 MD, acetone-d6): δ 8.96 (dd, 1H), 8.50 (dd, 1H), 8.32 (d, 1H), 8.24 (d, 1H), 8.03 (t, 1H), 7.73–7.68 (m, 4H), 7.63–7.59 (m, 2H), 7.32 (d, 2H), 2.75 (s, 3H), 2.53 (m, 1H), 2.03 (s, 6H), 1.97 (m, 1H), 1.56 (m, 1H), 1.46 (m, 1H).

Provenance & Evidence