Tetrahydrofuran → HCID 69159093, compound

Participants

Reaction Steps

To a solution of E-3-[3-(4-Bromo-phenyl)-acryloyl]4-methyl-5-phenyl-oxazolidin-2-one from Step 5 and Pd(OAc)2 (0.05 eq.) in THF (0.2M) was added portionwise CH2N2 until the reaction was completed. NMR of aliquots monitored the reaction. The resulting mixture was concentrated and flash chromatography (Hex:EtOAc; 3:2) to afford the two separate diastereoisomers. Each diastereoisomers were submitted to the procedures described in Step 2 and Step 3 to afford the (+) and (−) enantiomers of EXAMPLE 42

Provenance & Evidence