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HRID 861060作成日：2026年10月25日

4-Methoxybenzylamine → 4-(3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[(4-methoxyphenyl)methyl]-2-pyrimidinamine

https://huagongshe.com/reaction/861060

反応式

関与物質

役割名称HCID仕込み量
反応物4-MethoxybenzylamineHCID 75452—
反応物HCID 178505591HCID 178505591—
生成物4-(3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[(4-methoxyphenyl)methyl]-2-pyrimidinamineHCID 17849098280%

反応手順

This compound was synthesized by refluxing 2-chloro-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrimidine prepared in accordance with Example A-299 in 4-methoxybenzylamine overnight. The product, 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[(4-methoxyphenyl)methyl]-2-pyrimidinamine, was obtained as a off-white solid in 80% yield, mp: 183–185° C.; Anal. Calc'd for C21H18FN5O: C, 67.19; H, 4.83; N, 18.66. Found: C, 67.01; H, 5.11; N, 18.93.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07153959B2
出典データセットuspto-grants-2006_12
ORD IDord-471d3c339b9d4e3694c1629bd8873f1b
出典メモuspto-grants-2006_12