Pyrrolidine → 1-[2-(4-Methoxyphenyl)-7-(1-pyrrolidinyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone

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Reaction Steps

In a similar manner as described in Example 1 from 1-[7-(chloro)-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone (5.00 g, 16.6 mmol) and pyrrolidine, 1-[2-(4-methoxyphenyl)-7-(1-pyrrolidinyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone (4.68 g, 84%) was obtained as a yellow crystalline solid. 1H NMR (CDCl3): δ 7.79 (d, 1H), 7.50 (dd, 2H), 7.33 (t, 1H), 6.97 (dd, 2H), 6.12 (d, 1H), 3.84 (s, 3H), 3.74–3.70 (m, 4H), 2.11 (s, 3H), 1.99–1.95 (m, 4H); MS m/z 336 (M+1).

Provenance & Evidence