Butylamine → HCID 57444721, compound

HRID 861116Notes

Reaction equation

HRID 861116 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:18](=[O:20])[CH3:19])=[C:11]3[CH:12]=[CH:13][CH:14]=[C:15](Cl)[N:10]3[N:9]=2)=[CH:4][CH:3]=1.[CH2:21]([NH2:25])[CH2:22][CH2:23][CH3:24]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:18](=[O:20])[CH3:19])=[C:11]3[CH:12]=[CH:13][CH:14]=[C:15]([NH:25][CH2:21][CH2:22][CH2:23][CH3:24])[N:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 57444720HCID 57444720, compound

Product 1

HCID 57444721HCID 57444721, compoundYield 76%

Procedure

In a similar manner as described in Example 1, from 1-[2-(4-bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]ethanone (2.55 g, 7.3 mmol) and butylamine, 1-[2-(4-bromophenyl)-7-(butylamino)pyrazolo[1,5-a]pyridin-3-yl]ethanone (2.15 g, 76%) was obtained as a yellow oil. 1H NMR (CDCl3): δ 7.61 (m, 3 H), 7.43 (m, 3 H), 6.08 (d, 1 H), 6.02 (broad s, 1 H), 3.33 (q, 2 H), 2.12 (s, 3 H), 1.70 (m, 2 H), 1.44 (m, 2 H), 0.94 (t, 3 H); MS m/z 386 (M+1).

Sources & evidence

ORD record
ord-6a120519d59a4063bcdd94a841367145
Source dataset
uspto-grants-2006_12
Patent number
US07153855B2

Reaction notes

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