Ethyl 2-bromobenzoate → HCID 17933271, compound

HRID 861121Notes

Reaction equation

HRID 861121 reaction equation
[Br:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6]CC)=O.[Cl:13][C:14]1[N:19]=[C:18]([CH3:20])[CH:17]=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4](=[O:6])[CH2:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:13])[N:19]=1

Participants

3

Reactant 2

HCID 80186Ethyl 2-bromobenzoateHCID 876016-Chloro-2-picoline

Product 1

HCID 17933271HCID 17933271, compoundYield 77%

Procedure

In a similar manner as described in Example 1 from ethyl 2-bromobenzoate (50.0 g, 218 mmol) and 6-chloro-2-picoline (24 mL, 218 mmol), 1-(2-bromophenyl)-2-(6-chloro-2-pyridinyl)ethanone (52.4 9, 77%) was obtained as a yellow solid. 1H NMR (CDCl3): δ 7.53 (d, 1 H), 7.45 (d, 1 H), 7.25 (d, 1 H), 7.05 (d, 1 H), 6.97 (d, 1 H), 6.67 (d, 1H), 6.53 (d, 1H), 5.28 (s, 1H); MS m/z 310 (M+1).

Sources & evidence

ORD record
ord-97cc90a41eec4f00a5d5df10c4a1b9c8
Source dataset
uspto-grants-2006_12
Patent number
US07153855B2

Reaction notes

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