Thiophene-3-boronic acid → HCID 10279651, compound

Participants

Reaction Steps

In a similar manner as described in Example 29 from 2-(3-bromophenyl)-N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-7-amine (200 mg, 0.39mmol) and thiophene-3-boronic acid, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-[3-(3-thienyl)phenyl]pyrazolo[1,5-a]pyridin-7-amine (94 mg, 47%) was obtained as a yellow foam. 1H NMR (CDCl3): δ 8.00 (d, 1H), 7.92 (s. 1H), 7.81 (d, 1H), 7.67 (d, 1H), 7.57 (d, 1H), 7.49–7.42 (m, 2H), 7.40–7.34 (m, 2H), 7.32–7.27 (m, 1H), 6.38 (d, 1H), 6.09–6.03 (m, 2H), 5.22 (d, 1H), 4.36 (m, 1H), 4.00 (m, 1H), 2.15–2.05 (m, 4H), 1.82–1.56 (m, 12H); MS m/z 521 (M+1).

Provenance & Evidence