HCID 57494744, compound → HCID 57444746, compound

Participants

Reaction Steps

In a similar manner as described in Example 46 from 7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde (5.11 g, 17.8 mmol) and ethynylmagnesium bromide (89 mL, 0.5 M in tetrahydrofuran, 44.6 mmol) at 0° C. was obtained 1-[7-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol (5.22 g, 94%) as an off-white solid. 1H NMR (CDCl3): δ 8.02 (d, 1 H), 7.73 (d, 2 H), 7.18 (t, 1 H), 7.02 (d, 2 H), 6.97 (d, 1 H), 5.79 (m, 1 H), 3.87 (s, 3 H), 2.68 (m, 1 H), 2.25 (d, 1H).

Provenance & Evidence