HCID 57494746, compound → HCID 57444749, compound

Participants

Reaction Steps

In a similar manner as described in Example 46 from 2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridine-3-carbaldehyde (1.0 g, 2.9 mmol) and ethynylmagnesium bromide (6.4 mL, 0.5 M in tetrahydrofuran, 3.2 mmol) at 0 ° C., was obtained 1-[2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol (0.68 g, 68%) as a white solid. 1H NMR (DMSO-d6): δ 8.04 (m, 2 H), 7.87 (d, 1 H), 7.67 (d, 1 H), 7.49 (t, 1 H), 7.38–7.29 (m, 2 H), 6.27 (bs, 1 H), 5.69 (s, 1 H), 3.49 (d, 1 H).

Provenance & Evidence