Sodium ethoxide → HCID 86596769, compound

Participants

Reaction Steps

In a similar manner as described in Example 46 from 1-[2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-one (1.0 g, 2.8 mmol), N-cyclopentylguanidine hydrochloride and sodium ethoxide (4.1 mL, 21 wt % in ethanol, 3.6 mmol) at room temperature was obtained 4-[2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine (0.60 g, 46%) as a yellow crystalline solid. MS m/z 469 (M+1).

Provenance & Evidence