N,N-Dimethylethylenediamine → Asparaginamide

Participants

Reaction Steps

15 g (155 mmol) of polyanhydroaspartic acid (Mvisc. =19,000) are dissolved in 80 ml of DMF (anhydrous), if appropriate with gentle warming. First, 3.40 g (39 mmol) of freshly distilled dimethylaminoethylamine diluted in 20 ml of DMF are added dropwise to this solution and 1 g of anhydrous 2-hydroxypyridine is added and the mixture is stirred at room temperature for one day. 10 g (164 mmol) of aminoethanol are then added. After stirring for a further day the mixture is warmed at 50° C. for 2 h and repeatedly precipitated in anhydrous acetone.

Provenance & Evidence