Dimethylamine → HCID 22618560, compound

HRID 861250Notes

Reaction equation

HRID 861250 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[C:3]=1[S:23](Cl)(=[O:25])=[O:24].[CH3:27][NH:28][CH3:29]>>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[C:3]=1[S:23](=[O:25])(=[O:24])[N:28]([CH3:29])[CH3:27]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 22618564HCID 22618564, compound

Product 1

HCID 22618560HCID 22618560, compound

Procedure

A mixture of 5-amino-4-chlorosulphonyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-trifluoromethylpyrazole (1.2 g) and dimethylamine (17.6 ml of a 40% aqueous solution) was heated on a steambath for 1 hour, cooled, and poured onto crushed ice (50 g) to give a brown solid. This solid was filtered, dried, and recrystallized from toluene to give 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(N,N-dimethylsulphamoyl)-3-trifluoromethylpyrazole (0.8 g) as light brown crystals, m.p. 177.6°-178.6° C.

Workup

  1. temperaturewas heated on a steambath for 1 hour
  2. temperaturecooled
  3. additionpoured
  4. customto give a brown solid
  5. filtrationThis solid was filtered
  6. customdried
  7. customrecrystallized from toluene

Sources & evidence

ORD record
ord-f2426a6b89884c3f8338d23ac1b3f699
Source dataset
uspto-grants-1998_02
Patent number
US05714191

Reaction notes

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