Lithium hydroxide, monohydrate → HCID 73649701, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (1.4 g, 33.4 mmol) in 1:1 water-ethanol (20 mL) was added a solution of bis(4-(2-quinolylmethoxy)phenyl)-methyloximinoacetic acid ethyl ester (8.5 g, 14.2 mmol), prepared as in Example 3, in THF (80 mL) and ethanol (10 mL). The turbid reaction was stirred for 1 hour, and then was diluted with water (80 mL). The aqueous layer was washed with 1:1 ether-hexane (50 mL) and then filtered to remove fine solids. The filtrate was acidified to pH 4 with 1N HCl, and the precipitated solid collected by filtration and dried in vacuo to give bis(4-(2-quinolylmethoxy)phenyl)methyloximinoacetic acid (6.9 g, 85%): mp 183°-185° C.

Provenance & Evidence