HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 861334Generated: October 30, 2026
Sodium Acetate → 2-Acetoxy-2',4'-difluoroacetophenone
https://huagongshe.com/reaction/861334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| Catalyst | 2-Naphthylalanine | HCID 185915 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Acetoxy-2',4'-difluoroacetophenone | HCID 15253026 | 92.2% |
Reaction Steps
Add 191 g of 2-chloro-2',4'-difluoroacetophenone (Aldrich Chemical Co.) to a mixture of 246 g of sodium acetate, 3 g of Nal, and 3 L of DMF. Stir the mixture at 20° C. for 18 hr. then concentrate it to 1 L. Pour the residue into 6 L of cold dilute aqueous HCl and extract with EtOAc. Wash the extract with brine, dry it over anhydrous Na2SO4, filter the so-formed mixture, and evaporate the filtrate to leave a residue. Chromatograph the residue on silica gel, eluting with CH2Cl-2-hexane to obtain 198 g of the title compound. ##STR101##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05714490 |
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| Source dataset | uspto-grants-1998_02 |
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| ORD ID | ord-bd0ac4e5b46a46aca17674cb4ca454eb |
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| Source note | uspto-grants-1998_02 |
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