Ammonia → HCID 9928165, compound

Participants

Reaction Steps

The title compound was prepared in a analogous manner to Example 1 using 4-(benzothiophen-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride and 2-chloromethylbenzimidazole, m.p. 241° C. (dec.); (Found: C, 72.44; H, 5.41; N, 11.83. C12H19N3S.0.1H2O requires C, 72.63; H, 5.57; N, 2.10%); δH (DMSO-d6) 2.62 (2H, br s, tetrahydropyridinyl CH2), 2.77 (2H, m, tetrahydropyridinyl CH2), 3.24 (2H, d, J 2.8 Hz, tetrahydropyridinyl CH2), 3.87 (2H, s, NCH2Ar), 6.23 (1H, br s, CH=CR), 7.10-7.42 (1H, m, ArH), 7.45 (1H, d, J 8 Hz, ArH), 7.74 (1H, d, J 8 Hz, ArH), 7.76 (1H, dd, J 8, 2 Hz, ArH), 7.86 (1H, dd, J 8, 2 Hz, ArH), and 12.32 (1H, br s, NH); m/z (CI+, NH3) 346 (M+1)+.

Provenance & Evidence