Magnesium monoxide → HCID 19702789, compound

Participants

Reaction Steps

To a solution of 0.44 g of 1,1-bis-(4-chloro-6-trifluoromethylpyrimid-5-yl)methanol in 4.0 ml methanol were added 0.246 g magnesium oxide and 66 mg of 10% Pd/C (50% wet, Degussa). The mixture was then shaken on a Parr hydrogenation apparatus for 6 hours under 50 psi of hydrogen. The palladium catalyst and excess magnesium oxide were removed by filtration through dicalite, and the methanol filtrate was concentrated in vacuo to afford 318 mg of 1,1-bis-(4-trifluoromethylpyrimid-5-yl)methanol as an orange oil.

Provenance & Evidence