Formic Acid → HCID 19702798, compound

Participants

Reaction Steps

To a suspension of 6.6 mg of palladium diacetate (Pd(OAc)2), triethylamine (226 mg), and formic acid (204 mg) in 2 ml THF was added 410 mg of 2-(allyloxycarbonyl)-1-(4-methylpyrimidin-5-yl)pentan-1,3-dione. The mixture was refluxed for 3.5 hours, cooled and partitioned between ethyl acetate and water. The organic layer was dried with magnesium sulfate, filtered and evaporated to yield 290 mg of 1-(4-methylpyrimidin-5-yl)pentan-1,3-dione as an amber liquid.

Provenance & Evidence