HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 54307759, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | 1-(4-Methyl-5-pyrimidinyl)ethanone | HCID 13147450 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54307759 | HCID 54307759 | 98.2% |
Reaction Steps
To a solution of 28.2 g of 5-acetyl-4-methylpyrimidine in 250 ml of a chilled 1:1 mixture of benzene and DMF was added 33.6 g of tert-butoxy-bis(dimethylamino)methane dropwise. The solution was stirred overnight at room temperature. The solvents were evaporated in vacuo to yield 36.2 g of 3-dimethylamino-1-(4-methylpyrimidin-5-yl)-2-propen-1-one as a brick-red solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05714438 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-cd2d60766ba0489eb9c630e559751cb0 |
| Source note | uspto-grants-1998_02 |