Ethyl Acetate → HCID 19702788, compound

Participants

Reaction Steps

To a cooled solution of 300 mg of (4-methylpyrimidin-5-yl)-4-trifluoromethylpyrimidin-5-yl ketone in 4.5 ml of ethanol (EtOH) was added 30 mg of sodium borohydride in 1 ml EtOH dropwise over a period of 20 minutes. After stirring at 0°-5° C. for another 10 minutes, ethylacetate (25 ml) and 15 ml of 10% KH2PO4 (pH=3) were added followed by vigorous stirring. The layers were separated and the aqueous extracted twice with dichloromethane-methanol (10:1). The organic layers were combined, dried (MgSO4) and stripped to yield 183 mg of 1-(4-methylpyrimidin-5-yl)-1-(4-trifluoromethylpyrimidin-5-yl)methanol.

Provenance & Evidence