Dimethyl Sulfate → HCID 19703120, compound

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Reaction Steps

A mixture of 1-(4-bromophenyl)-3-methyl-pyrazol-5-one (3.6 g), 10N aqueous sodium hydroxide solution (1.57 ml), methanol (5 ml) and dimethylsulphate (1.4 ml) was heated at reflux for 2 hours. The crude product was purified by vacuum flash chromatography on silica gel (Merck Art 7736) using dichloromethane as eluent to give 1-(4-bromophenyl)-5-methoxy-3-methylpyrazole (21% yield) as a solid, m.p. 67°-68° C.; NMR: 2.9(3H,s), 3.4(3H,s), 5.5(1H,s) and 7.4-7.5(2H,d).

Provenance & Evidence