(4-Bromophenyl)boronic acid → HCID 19703148, compound

HRID 861420Notes

Reaction equation

HRID 861420 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[Br:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 79599(4-Bromophenyl)boronic acidHCID 27348955-Bromo-2-methoxypyridine

Product 1

HCID 19703148HCID 19703148, compound

Procedure

The 5-bromo-2-methoxypyridine was reacted with 4-bromobenzeneboronic acid using the procedure described in Example 25 for the preparation of the compound of formula 2. The product was purified by flash column chromatography on silica gel using a gradient of n-pentane to 3% ethyl acetate in n-pentane to give 5-(4-bromophenyl)-2-methoxypyridine as an oil (0.56 g), NMR: 3.9(3H,s), 6.9(1H,d), 7.61(4H,s), 8.0(1H,dd) and 8.5(1H,d).

Workup

  1. customThe product was purified by flash column chromatography on silica gel using a gradient of n-pentane to 3% ethyl acetate in n-pentane

Sources & evidence

ORD record
ord-3dc18233310d4eeaaaddf9566b6a8ce9
Source dataset
uspto-grants-1998_02
Patent number
US05714496

Reaction notes

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