反应详情

The above oil containing (-)-3-ethynyl-3-butyryloxyquinuclidine was treated with a solution of potassium hydroxide (2.24 g) in methanol (50 ml). The mixture was stirred at ambient temperature for 2 hours. The mixture was evaporated and deionised water (2 ml) was added to the residue to give a solid. The solid was collected by filtration, washed with water (2×2 ml) and dried under vacuum over phosporus pentoxide to give (-)-3-ethynyl-3-hydroxyquinuclidine (611 mg) as a solid, m.p. 199°-202° C., [α]19D =-56.1° (C=1.02, methanol).

1. customThe mixture was evaporated
2. additiondeionised water (2 ml) was added to the residue
3. customto give a solid
4. filtrationThe solid was collected by filtration
5. washwashed with water (2×2 ml)
6. customdried under vacuum over phosporus pentoxide