4-Pyridinepropanol → 4-Piperidinepropanol

HRID 861447Notes

Reaction equation

HRID 861447 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1>C(O)(=O)C.[Pd]>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][OH:10])[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 729234-Pyridinepropanol

Product 1

HCID 814974-Piperidinepropanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

3-(4-piperidinyl)propanol was prepared by hydrogenation of 3-(4-pyridyl)propanol in acetic acid in the presence of Pd/C according to the method described in J. Org. Chem., 1962, 27, 2966-2967.

Sources & evidence

ORD record
ord-1b9788bc7ca0454c9f9db37c73bc0bbb
Source dataset
uspto-grants-1998_02
Patent number
US05714497

Reaction notes

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