2,5-Dimethoxytetrahydrofuran → HCID 22097215, compound

HRID 861452Notes

Reaction equation

HRID 861452 reaction equation
[C:1]([NH:4][C:5]1[C:10]([NH:11][C:12](=[O:14])[CH3:13])=[CH:9][C:8]([Cl:15])=[C:7]([NH2:16])[CH:6]=1)(=[O:3])[CH3:2].CO[CH:19]1[CH2:23][CH2:22][CH:21](OC)O1>C(O)(=O)C>[Cl:15][C:8]1[CH:9]=[C:10]([NH:11][C:12](=[O:14])[CH3:13])[C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][C:7]=1[N:16]1[CH:19]=[CH:23][CH:22]=[CH:21]1

Participants

4

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 22097164HCID 22097164, compound

Product 1

HCID 22097215HCID 22097215, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3 g (12.4 mmol) of 4,5-diacetamido-2-amino-1-chlorobenzene and 1.6 g (12.4 mmol) of 2,5-dimethoxytetrahydrofuran in 150 ml of acetic acid were refluxed for 30 minutes. The reaction mixture was concentrated, the residue was washed with water and ethyl acetate, and the organic phase was worked up.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with water and ethyl acetate

Sources & evidence

ORD record
ord-a3ed864c2b5140d28ed03a182d6ff615
Source dataset
uspto-grants-1998_02
Patent number
US05714489

Reaction notes

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