Water → HCID 22097227, compound

HRID 861453Notes

Reaction equation

HRID 861453 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8]C(=O)C)[C:5]([NH:12]C(=O)C)=[CH:4][C:3]=1[N:16]1[CH:20]=[CH:19][CH:18]=[CH:17]1.[OH-].[K+].O>C(O)CO>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH2:12])=[CH:4][C:3]=1[N:16]1[CH:20]=[CH:19][CH:18]=[CH:17]1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 22097215HCID 22097215, compound

Product 1

HCID 22097227HCID 22097227, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A solution 1.4 g (4.8 mmol) of N-(2-chloro-4,5-diacetamidophenyl)pyrrole and 0.4 g (9.8 mmol) of potassium hydroxide in 25 ml of ethylene glycol was stirred at 60° C. for 30 minutes. The reaction mixture was then poured into water, extracted with ethyl acetate and worked up.

Workup

  1. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-a8ac6a40a8b8444cb5a77e6dadd6b87d
Source dataset
uspto-grants-1998_02
Patent number
US05714489

Reaction notes

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