HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → N-cyclohexyl-2-nitro-4-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene | HCID 8462 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-cyclohexyl-2-nitro-4-(trifluoromethyl)aniline | HCID 3853727 | — |
Reaction Steps
A solution of 50 g (0.22 mol) of 2-nitro-4-trifluoromethyl-1-chlorobenzene, 22 g (0.22 mol) of cyclohexylamine and 61 g (0.44 mol) of potassium carbonate in 600 ml of ethanol was refluxed for 4 hours. The reaction mixture was concentrated and then the crude product was washed with water and ether. The organic phase was worked up, and the product was purified by column chromatography on silica gel (mobile phase: heptane/ethyl acetate=5/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05714489 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-e2160795753e48de93e4647185278118 |
| Source note | uspto-grants-1998_02 |