Methyl 2,5-dimethoxyoxolane-2-carboxylate → 6-(2-Methoxycarbonyl-1-pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione

HRID 861468Notes

Reaction equation

HRID 861468 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[NH:8][C:7](=[O:16])[C:6](=[O:17])[NH:5]2.[CH3:18][O:19][C:20]([C:22]1(OC)[CH2:26][CH2:25][CH:24](OC)O1)=[O:21]>>[CH3:18][O:19][C:20]([C:22]1[N:1]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[C:12]([F:15])([F:14])[F:13])[NH:8][C:7](=[O:16])[C:6](=[O:17])[NH:5]3)[CH:24]=[CH:25][CH:26]=1)=[O:21]

Participants

3

Reactant 2

HCID 13152840Methyl 2,5-dimethoxyoxolane-2-carboxylateHCID 17800784HCID 17800784, compound

Product 1

HCID 220972116-(2-Methoxycarbonyl-1-pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione

Procedure

51 mmol of 6-amino-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione were reacted with 51 mmol of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran by the method of Example 5d.

Sources & evidence

ORD record
ord-ef69f9ca803f4210922a007604df5c3e
Source dataset
uspto-grants-1998_02
Patent number
US05714489

Reaction notes

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