Methyl 2,5-dimethoxyoxolane-2-carboxylate → HCID 19702952, compound

HRID 861479Notes

Reaction equation

HRID 861479 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:13])[C:8](=[O:12])[NH:9]2)=[CH:4][C:3]=1[Cl:14].[CH3:15][O:16][C:17]([C:19]1(OC)[CH2:23][CH2:22][CH:21](OC)O1)=[O:18]>C(O)(=O)C>[Cl:14][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[N:1]1[CH:21]=[CH:22][CH:23]=[C:19]1[C:17]([O:16][CH3:15])=[O:18])[NH:9][C:8](=[O:12])[C:7](=[O:13])[NH:6]2

Participants

4

Reactant 2

HCID 13152840Methyl 2,5-dimethoxyoxolane-2-carboxylateHCID 144236496-Amino-7-chloro-1,4-dihydro-2,3-quinoxalinedione

Product 1

HCID 19702952HCID 19702952, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

10 g (47.25 mmol) of 7-amino-6-chloro-2,3(1H,4H)-quinoxalinedione and 8.9 g (47.25 mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran in 150 ml of acetic acid were refluxed for 2 h. The precipitate was then filtered off with suction to yield 6.6 g (44%) of the product. Melting point>260° C.

Workup

  1. filtrationThe precipitate was then filtered off with suction

Sources & evidence

ORD record
ord-b94c846d4c6a49bc8ebc1e46ae990d41
Source dataset
uspto-grants-1998_02
Patent number
US05714489

Reaction notes

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