HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl bromoacetate → 1-(Methoxycarbonylmethyl)-7-(1-pyrrolyl)-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 6-(1-Pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione | HCID 22097086 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | 1-(Methoxycarbonylmethyl)-7-(1-pyrrolyl)-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione | HCID 22097057 | 40% |
Reaction Steps
35 g (118.6 mmol) of 6-(1-pyrrolyl)-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione (Example 2) were reacted with 23.8 g (155.5 mmol) of methyl bromoacetate as in Example 23. The mobile phase used for the chromatography was methylene chloride/ethyl acetate=3/2. 17.3 g (40%) of the product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05714489 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-90f7dc11c6a84f3fb75c26bb8df8f937 |
| Source note | uspto-grants-1998_02 |