2,5-Dimethoxytetrahydrofuran → HCID 22097062, compound

HRID 861530Notes

Reaction equation

HRID 861530 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:19])[C:8](=[O:18])[N:9]2[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].CO[CH:25]1[CH2:29][CH2:28][CH:27](OC)O1>C(O)(=O)C>[CH2:16]([O:15][C:13]([CH2:12][N:9]1[C:10]2[C:5](=[CH:4][C:3]([N+:20]([O-:22])=[O:21])=[C:2]([N:1]3[CH:25]=[CH:29][CH:28]=[CH:27]3)[CH:11]=2)[NH:6][C:7](=[O:19])[C:8]1=[O:18])=[O:14])[CH3:17]

Participants

4

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 22097166HCID 22097166, compound

Product 1

HCID 22097062HCID 22097062, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

30 g (97 mmol) of 7-amino-1-(ethoxycarbonylmethyl)-6-nitro-2,3(1H,4H)-quinoxalinedione and 16.1 g (121.5 mmol) of 2,5-dimethoxytetrahydrofuran in 500 ml of acetic acid were heated at 80° C. for 1 h. The mixture was then poured into ice-water, and the precipitate was filtered off with suction to yield 28.8 g (83%) of the product.

Workup

  1. filtrationthe precipitate was filtered off with suction

Sources & evidence

ORD record
ord-dbd19f4a3a2d4722a5ee2b0c02b455bf
Source dataset
uspto-grants-1998_02
Patent number
US05714489

Reaction notes

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