Hydrochloric Acid → HCID 131720459, compound

Participants

Reaction Steps

100.1 mg of the product of Example 15, 2 ml of ethanol and 0.1 ml of concentrated hydrochloric acid were refluxed for 4 hours 30 minutes and the mixture was cooled to ambient temperature, poured into 20 ml of water, neutralized with 2N sodium hydroxide and extracted with dichloromethane. The extracts were washed with water, dried,the solvent eliminated under reduced pressure and after chromatography on silica (eluant: AcOEt-cyclohexane 5-5), 34 mg of the expected product were obtained.

Provenance & Evidence