Cysteamine Hydrochloride → HCID 131718855, compound

HRID 861557Notes

Reaction equation

HRID 861557 reaction equation
[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4]([Cl:6])=[O:5].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>CCOCC>[ClH:6].[F:1][C:2](=[C:7]([F:9])[F:8])[CH2:3][C:4](=[O:5])[S:14][CH2:13][CH2:12][NH2:11]

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Product 1

HCID 131718855HCID 131718855, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3,4,4-trifluoro-3-butenoyl chloride (2.5 g, 0.0158 mole) and 2-aminoethanethiol hydrochloride (1.14 g, 0.010 mole) is slowly heated to reflux for 15 min. The mixture is cooled to room temperature and treated with dry ether and filtered. The product is recrystallized from absolute ethanol to give 0.8 g of the title compound as a off-white solid, a 34% yield. m.p. 95°-115° C.

Workup

  1. temperatureis slowly heated
  2. temperatureto reflux for 15 min
  3. filtrationfiltered
  4. customThe product is recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-5c69ca1368b1441db68893c5c4200f84
Source dataset
uspto-grants-1998_02
Patent number
US05714517

Reaction notes

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