Ammonia → N-(3,4,4-trifluoro-3-butenyl)ethanediamide

HRID 861559Notes

Reaction equation

HRID 861559 reaction equation
O=[C:2]([NH:9][C:10](=[O:15])[C:11](OC)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[NH3:16]>CO>[F:8][C:4](=[C:5]([F:7])[F:6])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([NH2:16])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86748464Oxo[(3,4,4-trifluoro-3-butenyl)amino]oxoacetic acid, methyl ester

Product 1

HCID 15239196N-(3,4,4-trifluoro-3-butenyl)ethanediamideYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Compound 142 (5.0 g, 0.0237 mole) in methanol (50 mL) is saturated with dry gaseous ammonia at room temperature. The precipitate is filtered, washed with methanol and dried to give 3.16 g of the title compound as a white solid, a 68% yield. m.p. 190°-220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-cf86f9d79dd2466bbb6c6ebc86f80d19
Source dataset
uspto-grants-1998_02
Patent number
US05714517

Reaction notes

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