Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 3-phenyl-DL-alaninate hydrochloride → N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| 반응물 | N-(benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide | HCID 19703709 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[(2-benzothiazolylamino)thioxomethyl]-DL-phenylalanine methyl ester | HCID 19703398 | 70.5% |
반응 단계
A solution of 1-[(2-benzothiazolyl) thiocarbamoyl] imidazole (1.30 g, 5.0 mmol) and DL-phenylalanine methyl ester hydrochloride (1.08 g, 5.0 mmol) in N,N-dimethylformamide (50 mL) was heated at 90° C. for 3 h. The reaction was cooled to room temperature, solvent removed under reduced pressure, recrystallized from ethyl ether-hexanes to provide 1.31 g (70%) of the titled product:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05714503 |
| 출처 데이터셋 | uspto-grants-1998_02 |
| ORD ID | ord-6ebd263c517a4d39a1c05a4f3e9c7d8b |
| 출처 메모 | uspto-grants-1998_02 |