HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 3beta-Iodoandrost-5-ene-17-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 3beta-Benzyloxy-5-androsten-17-one | HCID 53764908 | — |
| Product | 3beta-Iodoandrost-5-ene-17-one | HCID 53725900 | — |
| Product | 3beta-Hydroxy-16alpha-iodoandrost-5-en-17-one | HCID 69104100 | — |
Reaction Steps
Reaction of 3β,17-dihydroxyandrosta-5,16-diene 17-acetate 1 with mercuric acetate followed by treatment with potassium iodide yields the C-16αiodide which hydrolyses with acid to yield 3β-hydroxy-16α-iodoandrost-5-en-17-one, 2d. Reaction of 2d with silver fluoride yields 3β-hydroxy-16α-fluoroandrost-5-en-17-one, 2a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05714481 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-2413e6d0e7de45e89afbf90e39713346 |
| Source note | uspto-grants-1998_02 |