3-Butyn-2-amine, 4-[3-(4-fluorophenoxy)phenyl]-N-hydroxy- → Fenleuton

HRID 861683Notes

Reaction equation

HRID 861683 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:13]#[C:14][CH:15]([NH:17][OH:18])[CH3:16])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1.[O-:21][C:22]#[N:23]>>[OH:18][N:17]([CH:15]([C:14]#[C:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([O:6][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:20][CH:19]=2)[CH:8]=1)[CH3:16])[C:22]([NH2:23])=[O:21]

Participants

3

Reactant 2

HCID 107545733-Butyn-2-amine, 4-[3-(4-fluorophenoxy)phenyl]-N-hydroxy-HCID 178513472HCID 178513472, compound

Product 1

HCID 72059Fenleuton

Procedure

reacting the product of step 3 with cyanate to produce N-hydroxy-N-[4-(3-(4-fluorophenoxy)phenyl)-3-butyn-2-yl]urea.

Sources & evidence

ORD record
ord-dd3edd76ac4c44449b2c68f8cc7eaf89
Source dataset
uspto-grants-1998_02
Patent number
US05714633

Reaction notes

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