Acetic Anhydride → (1-Acetylpiperidin-4-yl)acetic acid

HRID 861727Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1)(=[O:13])[CH3:12]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 15125944-Piperidineacetic acid

Product 1

HCID 10442408(1-Acetylpiperidin-4-yl)acetic acidYield 99%

Procedure

4-Piperidinylacetic acid (5 grams) (35.0 mmoles) was reacted with acetic anhydride (10.7 grams) (105.0 mmoles) as described in Preparative Example 13A to give the title compound (Yield: 6.4 grams, 99%, MH+ 185).

Sources & evidence

ORD record: ord-80747849b1d5458a9a1e128c6c13beed
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05714609

Reaction notes

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