3-Pyridineacetic acid → HCID 10719054, compound

HRID 861748Notes

Reaction equation

HRID 861748 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.ClC1C=CC2C(N3CCNCC3)C3=NC=CC=C3CCC=2C=1.[N:46]1[CH:51]=[CH:50][CH:49]=[C:48]([CH2:52][C:53](O)=[O:54])[CH:47]=1.N1C=CC(CC(O)=O)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]([N:18]3[CH2:23][CH2:22][N:21]([C:53](=[O:54])[CH2:52][C:48]4[CH:47]=[N:46][CH:51]=[CH:50][CH:49]=4)[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12

Participants

5

Reactant 4

HCID 1083-Pyridineacetic acidHCID 342284-Pyridineacetic acidHCID 5255691HCID 5255691, compoundHCID 10760108HCID 10760108, compound

Product 1

HCID 10719054HCID 10719054, compoundYield 88.8%

Procedure

By substituting in Example 75, 4,8-chloro-11-(1-piperazinyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (0.3 g, 0.86 mmoles) (Preparative Example 41) for 8-chloro-11-(1-piperazinyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine and 3-pyridylacetic acid (0.1181 g, 0.86 mmoles) for 4-pyridylacetic acid and using the method described in Example 75 ,one obtains the title compound (0.357 g, 88%, MH+ 467).

Sources & evidence

ORD record
ord-4e28c5a50624433db4312d1f8bd5b569
Source dataset
uspto-grants-1998_02
Patent number
US05714609

Reaction notes

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