Sodium Hydroxide → HCID 10720002, compound

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Reaction Steps

To a solution of methyl (S)-2-benzyloxycarbonylamino-3-[4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidin-1-yl]propionate(2 g, 3.9 mmol) in 30 ml ethanol was added 10 ml of 1N NaOH aqueous solution. The mixture was then stirred at room temperature for 3 hours. After removing most ethanol under reduced pressure, the remaining mixture was diluted with ice-water and neutralized with acetic acid. The mixture was then extracted with chloroform (2×30 ml). The combined chloroform extract was washed with saline and dried over Na2SO4. After evaporating to dryness, the solid residue was recrystallized from ethanol to afford the title compound as a white crystalline. Yield:1.77 g (91%)

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