反应详情

2 g (5.2 mmol) of methyl 2-hydroxy-4-[3-hydroxy-3-(4,4-dimethylthiochroman-6-yl)-1-propynyl]benzoate and 50 ml of dichloromethane were introduced into a round-bottomed flask. 2.6 g (6.9 mmol) of pyridinium dichromate were added and stirring was carried out at room temperature for 8 hours. The reaction mixture was evaporated to dryness and the residue obtained purified by chromatography on a silica column eluted with a mixture of dichloromethane and hexane (50/50). After evaporating the solvents, 1.3 g (65%) of the expected ester was recovered in the form of a brown oil.

1. customThe reaction mixture was evaporated to dryness
2. customthe residue obtained
3. custompurified by chromatography on a silica column
4. washeluted with a mixture of dichloromethane and hexane (50/50)
5. customAfter evaporating the solvents, 1.3 g (65%) of the expected ester
6. customwas recovered in the form of a brown oil