Methyl 4-iodosalicylate → HCID 22619452, compound

HRID 861804Notes

Reaction equation

HRID 861804 reaction equation
[C:1]([CH:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH3:14])=[C:7]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:6]=1)[OH:4])#[CH:2].O[C:20]1[CH:29]=[C:28](I)[CH:27]=[CH:26][C:21]=1[C:22]([O:24][CH3:25])=[O:23]>>[OH:4][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH3:14])=[C:7]([C:15]([CH3:17])([CH3:16])[CH3:18])[CH:6]=1)[C:1]#[C:2][C:28]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:29]=1

Participants

3

Reactant 2

HCID 11380407Methyl 4-iodosalicylateHCID 22619472HCID 22619472, compound

Product 1

HCID 22619452HCID 22619452, compoundYield 86.3%

Procedure

Following the basic procedure of Example 11(d), by reacting 3.3 g (13.4 mmol) of α-ethynyl-3-tert-butyl-4-(propyloxy)benzenemethanol with 3.8 g (13.4 mmol) of methyl 2-hydroxy-4-iodobenzoate, 4.4 g (83%) of methyl 4-[3-hydroxy-3-(3-tert-butyl-4-propyloxyphenyl)-1-propynyl]benzoate were obtained in the form of a dark brown oil.

Sources & evidence

ORD record
ord-36a7cdfdfb824dc9ae2086deea80fe02
Source dataset
uspto-grants-1998_02
Patent number
US05716624

Reaction notes

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