Ethanol → HCID 19700410, compound

Participants

Reaction Steps

A The process is performed as described in Example 2A, but starting with 2.5 g of (2RS,4SR,5RS)-1-{2-[3-(3-benzyloxycarbonylphenyl)ureido]acetyl}-2-tert-butoxycarbonyl-5-(2-fluorophenyl)-4-morpholinosulphonylpyrrolidine, 0.25 g of 10% palladium-on-charcoal and 100 cm3 of ethanol under a hydrogen atmosphere (130 kPa). After treatment, 1.3 g of (2RS,4SR,5RS)-3-(3-{2-[2-tert-butoxycarbonyl-5-(2-fluorophenyl)-4-morpholinosulphonyl-1-pyrrolidinyl]-2-oxoethyl}ureido)benzoic acid are obtained [Rf=0.43; eluent: methylene chloride/methanol (90/10)].

Provenance & Evidence