HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 6,7-methylenedioxy-2-oxo-1-benzopyran-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-Hydroxy-1,3-dioxaindane-5-carbaldehyde | HCID 6710626 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 6,7-methylenedioxy-2-oxo-1-benzopyran-3-carboxylate | HCID 13193685 | 70.5% |
Reaction Steps
A mixture of 2-hydoxy-4,5-methylenedioxybenzaldehyde (1.16 g), diethyl malonate (1.34 g), piperidine (0.3 g), acetic acid (0.035 ml) and ethanol (30 ml) was refluxed for 4 hours. After the reaction mixture was cooled, the resulting crystal was collected by filtration to yield ethyl 6,7-methylenedioxy-2-oxo-1-benzopyran-3-carboxylate (1.29 g, 70%) having a melting point of 200°-201° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05716944 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-378f57f3f5e54944ab41fea8bd7f3a72 |
| Source note | uspto-grants-1998_02 |